![]() Typically, you request a webpage by typing its URL into your web browser. Due to its revolutionary approach to DOM manipulation and user interfaces, React dramatically changed Facebook’s approach to web development and quickly became popular in JavaScript’s ecosystem after its release to the open-source community. ![]() React simplified the development process by providing a more organized and structured way of building dynamic and interactive user interfaces with reusable components.įacebook’s newsfeed used it first. Jordan Walke, one of Facebook’s software engineers, created React to do just that. It wanted to offer users a richer user experience by building a more dynamic and more responsive user interface that was fast and highly performant. In doing so, the ReactJS framework combines the speed and efficiency of JavaScript with a more efficient method of manipulating the DOM to render web pages faster and create highly dynamic and responsive web applications.īack in 2011, Facebook had a massive user base and faced a challenging task. Rather than dealing with the whole user interface as a single unit, React.js encourages developers to separate these complex UIs into individual reusable components that form the building blocks of the whole UI. React’s primary role in an application is to handle the view layer of that application just like the V in a model-view-controller (MVC) pattern by providing the best and most efficient rendering execution. These components are individual pieces of a final interface, which, when assembled, form the application’s entire user interface. In React, you develop your applications by creating reusable components that you can think of as independent Lego blocks. ![]() It’s used for building interactive user interfaces and web applications quickly and efficiently with significantly less code than you would with vanilla JavaScript. The React.js framework is an open-source JavaScript framework and library developed by Facebook. For those who are new to web development, or trying to figure out what all the fuss is about, let’s look at React, how it works, and what makes it different from other JavaScript frameworks. ![]()
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![]() ![]() Set the Office Theme to Black and select the check box next to Never change the message background color.Ĭhange the look and feel of Office with themesĭark mode in Outlook. On the General page, look for Personalize your copy of Microsoft Office. The icons to switch dark mode on or off are disabled when you disable dark mode. If you prefer, you can disable dark mode so that the message window is always white when using the black theme. The nightshift option switches colors to. Reduce the harm of blue light on your eyes. Because this reflects everything back to you. When composing a message, you can turn dark mode on or off from the Message toolbar by selecting the dark mode icon to change the message window to white or black. Perfectly fit Zendesk, Freshdesk, Hubspot, Intercom, ServiceNow, HelpScout, Gorgias, Front, and Jira helpdesk platforms. Here the high quality theme use not the shining black as background and frame color. Select the moon icon to change the message window background to black. Select the sun icon to change the message window background to white. Now click on the Add to Chrome button, and after that, we can pin the extension. The first will be through the Android settings and the second is using the Dark M. In the following screenshot, we can see the chrome extension as follows. This video will show you two different ways to turn on Instagram dark mode. The browser-based extension we can add in Opera, Edge, or chrome. Chrome provides the Dark mode extension, and Jira supports it. WindowBlinds changes the look and feel of your Windows desktop by applying visual styles to your entire Windows environment. Dark mode theme for Visual Studio Code Pretty dark theme for you that doesn't want eye pain anymore if you like the theme don't forget to follow me on Github. ![]() ![]() ![]() Repérez la rubrique Dock theme, elle est positionnée par défaut sur « Current ». When reading a message, you can turn dark mode on or off by using the icon at the top of the message window. Now let’s see Jira dark mode based on the browsers. Lancez l’app CDock, vous arrivez sur l’unique fenêtre de gestion. Toggle between dark mode on and dark mode off This extension is an independent open-source project and is not related to Google Inc in anyways.Note: The theme you choose will be applied to all Microsoft 365 desktop applications. Supports "Calendar" and "Messages" services (as of version 0.5.0) You can ask the extension to automatically follow the system color scheme (turn dark theme on when the preferred color scheme is dark and turn it off when not) (this feature uses the JavaScript's matchMedia method to install a listener for prefers-color-scheme).Ĥ. You can append your custom CSS rules to the default dark theme from the options pageģ. You can define a period for the extension to automatically activate the dark themeĢ. enable-DarkMode is my personal interpretation based of Aseprites default theme created by Ilija Melentijevic & David Capello. 1920x1200 Alienware Desktop Background Red Organic Design. Using this extension you can customize many colors including background and link colors on the options page of the extension if you don't like the default configuration.ġ. 1920x1080 Full HD 1080p Dell Wallpapers HD, Desktop Backgrounds. Dark Theme: Android 10 finally brings a full system wide dark mode or you can. Do not be overwhelmed with the task of choosing the best Windows 10 themes/skin. MacBook with Lenovo C Dock duplicates image on external monitorsBest value. For maximum effect, you’ll need to install the Arc icon pack alongside the theme, also from DeviantArt. The extension supports all localized Google domains. Arc Theme includes several variations of its main black and white theme. A highly customizable dark theme for Google products (search, images, translate, and contacts) "Dark Theme for Google" extension brings a customizable dark theme to some of the Google services such as Google Search and Google Images. ![]() ![]() ![]() Tammy and Andy had bitterly accused him of abandoning her and he wants to explain himself. Meanwhile, Don sneaks into where Alice is being kept. The commanding officer, Stone ( Idris Elba), orders Alice executed even though she could hold the secret to curing the virus. However she is a carrier who could infect others with her saliva or blood. Alice has the rage virus teeming in her blood but is immune to its effects. An Army medical officer, Scarlet ( Rose Byrne), discovers an old bite wound on her and does a blood test. The NATO soldiers take Alice back to the Green Zone. There, Andy discovers Alice in the attic, delirious but alive. Tammy and Andy decide to sneak out into London and visit their old home to retrieve personal items. He tells Tammy and Andy that he tried to save their mother but there was no hope. Don manages one of the apartment buildings in the zone. Leaving the Green Zone is forbidden because troops are still cleaning up the corpses that have been rotting for six months. Snipers patrol the rooftops in case of another outbreak. Everyone lives in the Green Zone, a secured area on the Isle of Dogs, a peninsula on the East End of London. Among them are Don and Alice's children, Tammy and Andy ( Imogen Poots and Mackintosh Muggleton). An American-led NATO force has secured parts of London and is now allowing the return of English citizens who had been abroad during the outbreak. Twenty eight weeks later, the infected have all starved to death. ![]() They allow a young boy to enter the house but the infected have followed him and break in. Don and Alice are happy that their two children are on a school trip to Spain and thus away from the disaster. During the outbreak of the rage virus in England, Don ( Robert Carlyle) and his wife, Alice ( Catherine McCormack) hide in a country house with four other people.The synopsis below may give away important plot points. ![]() ![]() ![]() The active community where you can share ideas, thoughts and problems is supported by Aardman Academy Producer Katie Daniels, who has 20 years of experience working on productions at Aardman and was one of the key people behind the development of the Aardman Academy. ![]() ![]() Academic Lead Stuart Messinger - who worked on Aardman’s feature film “The Pirates! In an Adventure with Scientists!” before becoming one of the UK’s leading animation teachers - will also be available each week to help you with your weekly tasks. Alongside that, the course is run by former Aardman commercials director, filmmaker and Head of the Online Course Mark Simon Hewis, who will deliver live-streamed lectures once a week, where the entire course cohort will meet. This is a chance for you to be mentored and supported throughout the course. Once a week you will have a one-to-one video session with your mentor. Stop Motion 1 is taught by highly-experienced stop-motion professionals from the Academy Award®-winning Aardman studios, through video lessons that you can watch as many times as you want. Please sign up to the next Online Open Dayrun by the Course Leader via our Academy Website to find out more.Įach Aardman Academy course is devised by industry professionals with expertise in the specific field of study. Once you start making your final moving project, you decide how much time you want to dedicate to it. We estimate that the weekly activities will take you a minimum of five and a maximum of 10 hours to complete. There will be a fully supported active online community hub where you can share ideas, thoughts and problems throughout the course. From week 8 to 11 you are supported while you make your final moving image piece. When completed you will upload your finished task to our secure and private course community where your mentor will watch it before your weekly feedback session. The tasks are usually in the form of two films which invite you to attempt a task at home. ![]() You can watch them as many times as you want, pause, freeze, and step through frame by frame should you wish. These lessons have been filmed especially for you and this course alone. You will then be invited to explore the week's masterclasses and subsequent tasks, run and hosted by the animation team. You will be introduced to the week's activities via a live-streamed lecture with the course leader Mark Simon Hewis where you can ask questions, share ideas, discuss animation techniques and watch inspiring work. This course is aimed at people from the industry, university and self-taught animators to help improve their practice, skills and abilities. It falls under our Industry Training category of courses, so is taught at a level that expects some experience of animation beforehand. It covers 12-weeks of supported teaching and tasks to build the right foundations and develop practical skills in character animation, delivered by a team of highly experienced tutors and mentors. Working alongside Head of Animation Loyd Price and Aardman Co-founder and Creative Director Peter Lord we have devised Stop Motion 1: the first of our industry-led online stop-motion courses. An industry alternative to traditional education, our first three-month module has been devised and created by world-leading professionals from multi-award-winning and independent studio Aardman and will be taught to you from the comfort of your own home through an online learning environment and community. ![]() ![]() ![]() So it seems as though the large quantity of neurons enables adolescents to find their way along winding paths that no longer readily suggest themselves to adults. The more activity was measured in the side-roads of the frontal cortex, the better the adolescents performed in the task. They use the frontal cortex more in finding creative solutions than adults do. But when it comes to the aha moment, adolescents still have easy access to side-roads, so they are more inclined to leave the beaten track. One of the reasons adolescents have such trouble planning is because the frontal cortex is still developing it’s still a winding path through the forest. But as the forest gets older and more walkers pass that way, certain paths become well-trodden and established, whereas others are taken less often and eventually disappear.Īdults use the frontal cortex like a multi-lane motorway for targeted problem-solving. ![]() Think of it as a forest where there aren’t any clear paths, so you can criss-cross your way through as you wish. This process enables the frontal cortex to work more and more efficiently. The number of neurons in the frontal cortex increases from birth and peaks in adolescence, after which the effective neurons remain in place and the superfluous ones are removed. The frontal cortex turned out to play a key role here. We then investigated which areas of the brain were active at this point when people experienced the aha moment. On average, adolescents identified the right solution more quickly than adults they were quicker to reach the aha moment. To investigate this aha moment, we got adolescents and adults to carry out tasks involving moving matchsticks to make new figures. It does have to be useful and practical, though, not just some crazy idea some sort of out-of-the-box thinking leads to an aha insight that can actually be used. What is it that makes adolescents so good at this kind of thing? At the Brain and Development Lab in Leiden we’ve been doing research into what is sometimes known as ‘aha insight’, an important component of creativity.Ī creative thought is one that leads to a new insight that hasn’t been thought of before. And yet it can be so difficult to get them interested in watching news programmes or doing their homework. No matter how carefully we adults read the manual and methodically follow all the steps – and no matter that we can draw on a wealth of experience with similar types of devices in the past – we still can’t compete with adolescents here. Give a fifteen-year-old an iPad, smartphone, or some other device, and you can bet he or she will have it all worked out much more quickly than most adults. ![]() ![]() Though it would seem likely that the testimony of children's writers should help us to define and delimit children's literature, Bator notes the surprising number of children's writers who "profess not to write consciously for children." He suggests that the low status of children's literature is an important reason why so many authors are reluctant to see themselves as writing for a child audience. ![]() Bator reprints Clifton Fadiman's comprehensive "Case for a Children's Literature" which focuses on significant characteristics of children's books and "demonstrates that literature's lineage and its contributions," as well as John Rowe Townsend's brief and more pragmatic definition of children's books as those consigned to the children's shelves by a consensus of adults and children. Brief introductions to each section and sub-section allow Bator the opportunity to offer a kind of running commentary on critical priorities and strategies and to set each piece in a critical context.ĭefining children's literature is not as easy as it looks. The second part presents discussions of the various genres of children's literature in order to "map the territory" in some detail. ![]() In the first part of the book, Bator has collected essays centering on the definition of children's literature, its status, and the range of critical approaches to it. The selections, therefore, "not equal in length," "nor equally valued," "range from the commonplace to the unique." But all the pieces subscribe to the view that "children's literature can and should be subject to serious critical scrutiny," and the result is a very useful book, which both documents the recent past of children's literature criticism and suggests directions for its future. Some have clearly been chosen not for their intrinsic merit, but rather because they represent some position he wished to include. Bator has deliberately chosen "assertive and analytical articles" representing a wide range of opinions. In this new anthology, Bator offers a selection of essays from past and present which attempt, in various ways, to answer these questions. "The critics continually have had to maintain the necessity for and the propriety of the criticism before gaining clear passage to the actual territory." Still, some of the questions which have pre-occupied the critics seem important: What is children's literature? How has it been perceived in the past? How should it be approached now? ![]() Children's literature studies have all too often "run aground on the sandbar of apologetics," says Robert Bator. ![]() ![]() Some devices come with a carrying case and extra batteries as part of a set. What accessories are needed to use a digital vernier caliper?īecause it is a precise measuring tool, a protective cover is essential to ensure its longevity. Digital calipers run on battery power, such as 1.5-volt alkaline batteries, and some models have an on/off switch. Many of these devices also feature a locking thumb screw, that helps keep the jaws in place. LCD screen: a liquid crystal display that shows the precise measurement in a digital format.Small internal jaws: located on the inside, these measure the inside diameter or width of an object.Large external jaws: located on the outside, these measure the outside width or diameter of an object.Retainer: blocks any moving parts in order to transfer measurement easily.Vernier scale: shows interpolated metric measurements to 0.1 of a millimetre or more or in fractions of an inch for U.S.Main scale: a metric measurement marked in millimetres or inches and fractions for U.S.Depth rod, probe or measuring blade: this measure the depth of an object, such as a hole.There are several essential parts of a digital vernier caliper. What are the parts of a digital vernier caliper? When it contacts the bottom of a hole, a reading is shown on the digital display or can be determined manually with graduations along a vernier scale. They have a spindle that is adjusted by rotating a thimble until the rod/beam contacts the bottom of a hole being measured. Materials used for digital vernier calipers include stainless steel or carbon fibre. Depth micrometers take measurements of slots, steps, holes, and projections. In most cases, a digital vernier caliper is able to measure anything that is within 150 millimetres, although some larger caliper can measure twice that amount. The digital version of a vernier caliper displays the results of the measure via an LCD screen attached to the device. What is a digital vernier caliper?Ī digital caliper is a measuring tool used to provide an exact reading for the inside, outside and depth of small objects. ![]() ![]() ![]() For extremely precise measurements rendered in a digital format, a digital vernier caliper is the tool of choice. A device that has been around for centuries many calipers us a hinge that is connected to a pair of legs that open and close on the hinge and allow for the measurement to be taken for more precise measurements, especially of small objects, a vernier caliper is necessary. When it is important to know the precise distance between the opposite sides of an object, a caliper is often the tool of choice. ![]() ![]() ![]() Multiple plays that had never been staged before were given full productions: elaborate sets, costumes, A-list actors and directors, even original music.Īnother factor in the decision to end the festival, said Fleming, is that other theaters got in on the act. Humana was a major, expensive undertaking. "It's not a sustainable model based on how we've moved into our 21st century," said Robert Barry Fleming, executive artistic director of Actors Theatre of Louisville, which produced the festival for some 40 years. Perhaps even more jarring to those in regional theater, the Humana Festival for New American Plays, one of the most important showcases for new work, isn't coming back. The pandemic shutdowns made things worse as audiences dried up two longtime incubators for new play development closed: The Sundance Theatre Lab and The Lark. That's because there's not a lot of money in regional theater, especially for those stages that take risks on new work. The Alleyway Theatre's production of The Magnolia Ballet by Terry Guest stars two local Buffalo actors, Nigel Reynolds and Shawn Adiletta. He says applying for grants is 80% of his job. Handley, one of only two full-time employees at Alleyway, said the theater's survival is dependent on grants and an annual production of A Christmas Carol. And the kind of theater that we are doing is truly not something that they probably are interested in." ![]() "Because it is people of a certain age who are coming to see theater. "That's what keeps me up at night," he said. ![]() Jackson's Broadway hit A Strange Loop, saying it was "just as poetically resonant and ambitious," as Jackson's Tony Award-winning play.Įven so, a new play by an unknown writer is not an easy sell to audiences, The Alleyway's Handley said. Eric Watkins was the production's lighting designer.Ĭhris Jones, theater critic for The Chicago Tribune and The Daily News, compared a Chicago production of The Magnolia Ballet, which starred Guest himself, to Michael R. Playwright and actor Terry Guest in a production of his play, The Magnolia Ballet, from About Face at the Den Theatre in Chicago. But it's also funny, with some awkward dancing to Brittney Spears by the sole white character and irreverent jokes about historical figures - including one imagining the character of Prissy from Gone With The Wind as a porn star. One gay teen struggles to come out to his hyper-masculine dad. The Magnolia Ballet, which opened Alleyway's new season, is a tale of tension and release, identity and shame. Now, the theater occupies the whole building, leased from the city of Buffalo. When the bus station moved in the late 1970s, The Alleyway shared the space with the local police precinct. Terry Guest used those funds to travel to The Alleyway, a theater contained in a former 1941 Greyhound Bus Station. Playwrights also receive funding to travel to those premieres so they can experience their work, "in the hands of different directors, on the bodies of different actors and as reflected through the audiences and critics of all these different communities." If three theaters that are members of the Network agree to produce the same new play they're eligible for $7,500 each, "regardless of their budget size," explained Nan Barnett, executive director of the network. The Williamston Theatre in Michigan also liked it and - bingo! - they had enough theaters involved to get money for a "rolling world premiere," from the National New Play Network. "I read it and thought 'Oh my god this is fantastic,'" said Handley. He liked it and gave it to Chris Handley at The Alleyway Theatre in Buffalo. One of the directors in that reading gave the script to Bill Simmons at The Phoenix Theatre in Indianapolis. It was on Wednesday that a judge ruled that Britney's father, Jamie Spears', involvement in her conservatorship was no longer in her best interests.īritney responded by saying she was on “cloud 9” while her fans celebrated wildly outside the court building.Playwright Terry Guest poses with Carlos Jones who directed a production of The Magnolia Ballet at Alleyway Theater in Buffalo, N.Y., on Sept. One commented: "Britney used her first day of non-jamie conservatorship to post nudes and I’m inspired."Īnother said: "QUEEN U GOTTA START CHARGING FOR THESE OUR EYES AINT WORTHY."Ī third responded: "As you should a born again free woman." Signing up couldn't be easier! Simply enter your email address in the box further up the page or click here to view our wide range of newsletters.įans were also loving the new photos showing Britney seemingly enjoying her freedom from her father. If, like us, you love a good dose of celebrity gossip then we've got you covered.įrom Lorraine Kelly and Janey Godley to Gordon Ramsay and Sir Rod Stewart, our weekly Showbiz newsletter is packed with the latest news on your favourite stars from Scotland and beyond. ![]() ![]() The color is matched using the print plugin software instead of the retouch software window. * Startup and color settings for these software must be done manually. (Adobe Photoshop Lightroom Classic, Adobe Photoshop Elements, Nikon NX Studio, Nikon ViewNX-i) * Retouching software compatible with Epson Print Layout (Adobe Photoshop Lightroom Classic, Adobe Photoshop Elements, Canon Digital Professional) * Retouching software compatible with Canon Print Studio Pro 2.2.0 or later 1, Professional Print & Layout Ver.1.2.2 or later PIXMA PRO-1, PIXMA PRO-10, PIXMA PRO-10S, PIXMA PRO-100, PIXMA PRO-100S, imagePROGRAF PRO-1000 (Asia: PRO-500), imagePROGRAF PRO-300, PIXMA PRO-200 This page provides a simple breakdown of the function of both solutions so you can build the creative workflow that suits your needs. Quick Color Match and ColorNavigator - Building Your Color Editing WorkflowĮIZO has developed two unique software solutions for managing and matching color in the creative workflow - Quick Color Match and ColorNavigator. This guide explains in more detail how you can retouch and print photos with accurate color using Quick Color Match. Quick Color Match Easy Screen-to-Print Color Matching Guide The colors on screen are reliable so you can retouch and print with confidence! Users with Photoshop installed can start working in their software right away with Quick Color Match's easy drag-and-drop function. Trust the Colors Displayed on Your Screen Simply choose your installed printer and paper, and you can get right to printing your color-matched photos! Simply choose the paper size, type, and quality and you can quickly print your photo without worrying about navigating through several windows of technical settings and options. With either Canon Print Studio Pro or Epson Print Layout print plugin installed, Quick Color Match will automatically select the print profile and color and soft proofing options recommended by EIZO. You can also adjust the brightness and white point manually.ĭragging and dropping your photo to the Quick Color Match window automatically opens Adobe Photoshop and adjusts to EIZO's recommended color settings based on the printer and paper being used. Quick Color Match automatically adjusts your ColorEdge monitor's gain, brightness, gamma, and color space (Adobe RGB) and creates a profile for these settings that is optimized for your selected printer paper type. ![]() Simply drag and drop your photo in the Quick Color Match window to automatically start the process. Quick Color Match greatly simplifies the process by automatically adjusting to the ideal monitor, retouching software, and printer settings so you can focus on editing your photos and print your work quickly and hassle-free. By combining the know-how and expertise of these leaders in the creative industry, EIZO has developed an ideal software solution that greatly simplifies the color matching and printing workflow for photo enthusiasts and professional photographers alike.įor English, turn on closed captions on YouTube.Įven with all the right equipment, color matching can be a tedious process - from monitor adjustment to determining the best retouch software and printer settings - achieving an accurate print takes a great deal of time. Quick Color Match was developed under a first-ever collaboration between EIZO and Adobe, Canon, and Epson. ![]() Collaboration with Adobe, Canon, and Epson ![]() ![]() This idea is further reinforced by studies that suggest that other herpesviruses, such as the Epstein Barr virus (EBV) and human herpesvirus-6 (HHV-6), may be related with multiple sclerosis (MS) and Alzheimer’s disease (AD), giving herpesviruses increased attention in the last decades on their potential roles in neurological diseases ( Casiraghi et al., 2012, 2015 Leibovitch et al., 2018). These observations have led to the notion that infection with HSV-1 may promote, or contribute to neurodegenerative disorders in humans ( Dobson et al., 2003 Otth et al., 2009 Martin et al., 2011 Buscarinu et al., 2017). On the other hand, because the immune system of an individual tends to decay upon aging, opportunities arise for HSV-1 to reactivate in the organism and spread to tissues such as the brain. The fact that HSV-1 is not invisible to the immune system and that immune cells are commonly found adjacent to infected cells, suggests scenarios in which immune cells infiltrating the CNS may somewhat contribute to chronic inflammatory processes that can be detrimental to the function of this tissue ( White et al., 2012 Van Velzen et al., 2013 Ma et al., 2014). This notion is supported by the fact that some studies have reported the presence of HSV-1 DNA in up to 65%–75% of the brains of seropositive individuals, without clinical signs of active infection or neurological illnesses ( Baringer and Pisani, 1994 Mori, 2010). Regardless if the individual is symptomatic or asymptomatic after infection with HSV-1, the lifelong presence of this virus in the organism may produce in some hosts alterations in cellular processes that are required for normal neuronal cell function, which could eventually lead to pathology in the brain in a fraction of seropositive persons ( Zambrano et al., 2008 Martin et al., 2014b). Nevertheless, HSV-1-infected asymptomatic individuals are significant reservoirs for this virus and contribute to its transmission through shedding ( Miller and Danaher, 2008 Ramchandani et al., 2016). ![]() Worldwide, nearly 60% of the population has antibodies against this virus, however only 20%–40% of those that are infected develop symptoms ( Looker et al., 2015). The virus is usually acquired during childhood and produces lifelong infections due to its ability to infect and remain latent in neurons ( Kramer et al., 2003). HSV-1 is the most common cause of sporadic encephalitis in adults, as well as the leading cause of infectious blindness in developed countries due to herpetic keratitis ( Whitley and Roizman, 2001 Lairson et al., 2003). ![]() Importantly, HSV-1 is a neurotropic pathogen with a wide spectrum of clinical disorders ranging from harmless skin manifestations, such as oral and facial lesions to severe infection of the central nervous system (CNS). Herpes simplex virus type-1 (HSV-1) is an enveloped double-stranded DNA virus belonging to the Herpesviridae family, that has a genome of approximately 152 kbp encoding more than 80 different open reading frames (ORFs Boehmer and Nimonkar, 2003). Furthermore, we discuss the impact of HSV-1 infection on brain inflammation and its potential relationship with neurodegenerative diseases. We review potential cellular and molecular mechanisms leading to neurodegeneration, such as protein aggregation, dysregulation of autophagy, oxidative cell damage and apoptosis, among others. Here, we review and discuss acute and chronic infection of particular brain regions by HSV-1 and how this may affect neuron and cognitive functions in the host. ![]() Importantly, there is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders. Although HSV-1 encephalitis can be treated with antivirals that limit virus replication, neurological sequelae are common and the virus will nevertheless remain for life in the neural tissue. Once in the central nervous system (CNS), the virus can either reside in a quiescent latent state in this tissue, or eventually actively lead to severe acute necrotizing encephalitis, which is characterized by exacerbated neuroinflammation and prolonged neuroimmune activation producing a life-threatening disease. Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain without evident clinical symptoms.
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